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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
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Reduced spinal reflexes following intrathecal baclofen in the rabbit

J S Kroin, R D Penn, R L Beissinger

    Experimental Brain Research
    |January 1, 1984
    PubMed

    Abstract:

    Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5-5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 micrograms or less, the forelimbs were unaffected.

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