[Splenocyte functional activity in mice growing the syngeneic transplantable hepatoma 22a]

The growth of syngeneic transplantable hepatoma 22a is not accompanied by alteration of functional activity of T-lymphocytes in the spleens of tumor-bearing hosts as evidenced by means of PHA-blasttransformation test. The contents of T-lymphocytes in the spleens of tumor-bearers was non changed. The cytotoxic activity of the splenocytes towards hepatoma 22a cells was increased either in vivo (Winn-test) or in vitro (cytotoxic test) as compared with splenocytes of intact mice. By means of the test of inhibition of peritoneal macrophage adherence, the increased level of sensibilization of splenocytes towards tissue antigens was shown in mice hearing hepatoma 22a.