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Corneal transplantation for herpes simplex keratitis
American Journal of Ophthalmology
|May 1, 1983
Summary
This study found that 80% of penetrating keratoplasty corneal transplants remained clear, with 59% achieving good vision. Herpes simplex keratitis recurrence after corneal transplantation was 19%.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Transplantation Immunology
Background:
- Penetrating keratoplasty (PKP) is a common surgical procedure for corneal blindness.
- Long-term outcomes and prognostic factors for PKP, especially in cases involving herpes simplex keratitis (HSK), require ongoing evaluation.
Purpose of the Study:
- To evaluate the long-term outcomes of penetrating keratoplasty performed between 1970 and 1979.
- To assess the impact of preoperative vascularization and HSK on graft clarity, visual acuity, and rejection rates.
Main Methods:
- Retrospective analysis of 107 PKPs in 99 patients performed at Wills Eye Hospital from 1970-1979.
- Follow-up periods ranged from 1 to 12 years (median, 3 years).
- Analysis included graft clarity, visual acuity, and rejection events, with a focus on preoperative vascularization and HSK status.
Main Results:
- Overall graft clarity was 80% (86/107 transplants).
- Good to excellent visual acuity (≥20/60) was achieved in 59% (63/99 eyes).
- Preoperative vascularization did not significantly impact visual outcome, graft clarity, or rejection. Recurrent dendritic keratitis occurred in 19% of HSK cases.
Conclusions:
- Penetrating keratoplasty demonstrated favorable long-term graft survival and visual outcomes during the study period.
- Preoperative vascularization was not a significant predictor of PKP success.
- A 19% recurrence rate of herpes simplex keratitis necessitates careful management post-transplantation.