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Related Experiment Videos

Liposome/white-cell interactions in vivo.

T N Palmer, J P Warner

    Bioscience Reports
    |May 1, 1983
    PubMed
    Summary

    Intravenous liposomes did not cause white blood cell clumping or lung blockage in rats. This suggests liposome administration is unlikely to harm lung function by altering white cell behavior.

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    Area of Science:

    • Pharmacology
    • Immunology
    • Nanotechnology

    Background:

    • Liposomes are frequently used as drug delivery systems.
    • Potential interactions between liposomes and white blood cells (leukocytes) require investigation, particularly concerning lung function.
    • Pulmonary leukostasis, the obstruction of lung capillaries by leukocytes, is a critical concern.

    Purpose of the Study:

    • To determine if intravenous liposome administration induces granulocyte aggregation.
    • To assess the impact of liposomes on pulmonary leukostasis.
    • To investigate potential interactions between liposomes and white blood cells.

    Main Methods:

    • Rats were intravenously administered radiolabeled white blood cells ([111In]tropolanate).
    • Positively and negatively charged liposomes containing [99mTc]DTPA were also administered intravenously.
    • Blood clearance and tissue distribution of both radiolabels were monitored.

    Main Results:

    • Liposome administration did not alter the blood clearance or tissue distribution of the radiolabeled white blood cells.
    • Conversely, white blood cell administration did not affect the liposomes' blood clearance or tissue distribution.
    • No evidence of granulocyte aggregation or pulmonary leukostasis was observed.

    Conclusions:

    • Intravenous administration of liposomes does not appear to promote granulocyte aggregation.
    • Liposome-white cell interactions are unlikely to compromise lung function following intravenous administration.
    • These findings support the safety of intravenous liposome-based therapies regarding pulmonary hemodynamics.

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