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Pulmonary function in insulin-dependent diabetes mellitus with limited joint mobility
The American Review of Respiratory Disease
|November 1, 1984
Summary
Patients with severe limited joint mobility (LJM) linked to insulin-dependent diabetes mellitus (IDDM) show significantly reduced lung volumes. This suggests LJM may impact respiratory mechanics in IDDM patients.
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Rheumatology
Background:
- Insulin-dependent diabetes mellitus (IDDM) is associated with collagen metabolism disturbances.
- Limited joint mobility (LJM) is a potential manifestation of these collagen abnormalities.
Purpose of the Study:
- To investigate if LJM in IDDM patients is linked to altered respiratory mechanics.
- To determine if LJM is associated with changes in lung volumes and airflow.
Main Methods:
- Studied 23 IDDM patients, divided into groups with and without severe LJM.
- Measured lung volumes (FVC, FEV1, TLC, RV) and maximal expiratory flow-volume curves.
- Matched groups for age, sex, and glycemic control.
Main Results:
- Patients with severe LJM exhibited significantly decreased forced vital capacity (FVC) and forced expiratory volume in one second (FEV1).
- Total lung capacity (TLC), thoracic gas volume (TGV), and residual volume (RV) were also significantly lower in the severe LJM group.
- No evidence of airflow obstruction was found in either group.
Conclusions:
- Severe LJM is associated with a significant reduction in lung volumes among IDDM patients.
- This reduction may stem from decreased lung compliance or restricted chest wall expansion.
- Altered respiratory mechanics could be another manifestation of generalized collagen disturbance in IDDM with LJM.