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[Prostatic tissue and fluid levels of DL-8280]
Hinyokika Kiyo. Acta Urologica Japonica
|September 1, 1984
Summary
DL-8280, a novel pyridone carboxylic acid, shows significant prostate concentration after oral administration in humans. This drug concentration in prostatic tissue and fluid is dose-dependent, exceeding serum levels.
Area of Science:
- Pharmacology
- Drug Metabolism
- Urology
Context:
- Prostate cancer treatment
- Antibacterial agents
- Pyridone carboxylic acid derivatives
Purpose:
- To determine the concentration of DL-8280 in human prostatic tissue and fluid.
- To evaluate the dose-dependency of DL-8280 prostate accumulation.
- To compare prostatic DL-8280 levels with serum levels.
Summary:
- Oral administration of DL-8280 resulted in significant accumulation in prostatic tissue and fluid.
- Prostate tissue and fluid concentrations of DL-8280 were dose-dependent.
- Ratios of prostatic tissue to serum levels ranged from 1.62-1.79, and prostatic fluid to serum levels ranged from 1.65-1.96.
Impact:
- DL-8280 demonstrates favorable pharmacokinetic properties for prostate targeting.
- This pyridone carboxylic acid may be a promising therapeutic agent for prostate conditions.
- Understanding drug distribution is crucial for optimizing treatment efficacy and minimizing systemic exposure.