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T lymphocyte surface antigens in primates.

N L Letvin, N W King, E L Reinherz

    European Journal of Immunology
    |April 1, 1983
    PubMed
    Summary
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    Monoclonal antibodies reveal conserved T cell structures across primate species. These findings highlight the evolutionary relationships between human and primate T lymphocytes, aiding future research.

    Area of Science:

    • Immunology
    • Primatology
    • Evolutionary Biology

    Background:

    • T lymphocytes play a crucial role in the immune system.
    • Understanding T cell surface structures is vital for immunology and evolutionary studies.
    • Monoclonal antibodies offer precise tools for analyzing cell surface markers.

    Purpose of the Study:

    • To investigate the structural conservation of T lymphocyte surface determinants across diverse primate species.
    • To assess the utility of monoclonal antibodies in comparative primate immunology.
    • To explore the relationship between phylogenetic distance and T cell marker sharing.

    Main Methods:

    • Peripheral blood mononuclear cells from various primate species were isolated.
    • Cells were analyzed for binding to a panel of monoclonal antibodies specific for human T lymphocytes.

    Related Experiment Videos

  • Erythrocyte rosette receptor expression and other T cell surface determinants were examined.

    • Main Results:

    • Significant structural conservation of the erythrocyte rosette receptor was observed on T cells between lemurs and humans.
    • The degree of shared T cell-specific surface determinants correlated with phylogenetic distance among primate species.
    • Monoclonal antibody binding patterns provided insights into T cell evolution.

    Conclusions:

    • The erythrocyte rosette receptor on T cells is highly conserved across a wide phylogenetic range of primates.
    • Monoclonal antibodies are valuable tools for studying T cell surface structures and evolutionary relationships in primates.
    • These findings pave the way for further structural and functional characterization of primate T lymphocyte-specific surface molecules.