Screening for carcinogens by DNA-synthesis inhibition test using mouse L-cells

Bacterial test systems for potential carcinogens sometimes give false negative results. To overcome this problem, several short term test systems have been described. One of them is the DNA-synthesis inhibition test described by Painter (1977). Our DNA-synthesis inhibition test system using mouse L-cells gave positive results when monocrothaline, phenacetin and thioacetamide, which were negative in the Ames test, were tested.