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[Morphological changes in different cells of the taste bud]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|March 1, 1984
Summary
Colchicine application to the glossopharyngeal nerve reduces foliate papillae taste buds and their cell count. This study challenges the idea that different taste bud cells originate from a single cell type.
Area of Science:
- Neurobiology
- Histology
- Cell Biology
Context:
- The glossopharyngeal nerve innervates taste buds, including foliate papillae.
- Taste buds are complex sensory structures composed of various cell types.
Purpose:
- To investigate the effect of colchicine on foliate papillae taste bud morphology and cell composition.
- To evaluate the hypothesis regarding the origin of different taste bud cell types.
Summary:
- Application of colchicine to the glossopharyngeal nerve led to a decrease in the area and cell number of foliate papillae taste buds.
- Morphological analysis revealed a shift in cell type correlation, with an increase in intermediate cells and a decrease in dark cells.
- These findings do not support the hypothesis that morphologically distinct taste bud cells derive from a single progenitor cell type.
Impact:
- Provides new insights into taste bud cell differentiation and regeneration.
- Challenges existing models of taste bud cell lineage.
- Offers a basis for further research into the cellular mechanisms of taste perception.