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The proliferative activity of antibody forming cells in the mouse bone marrow
The proliferative activity of antibody-forming cells was studied in the bone marrow of mice immunized with either sheep erythrocytes (SRBC), TNP-LPS or DNP-Ficoll. Peak proliferative activity was found during the first few days of the response. Elimination of the proliferating cells in this period caused a profound and longlasting suppression of the antibody formation in the marrow.
The proliferative activity of antibody-forming cells was studied in the bone marrow of mice immunized with either sheep erythrocytes (SRBC), TNP-LPS or DNP-Ficoll. Peak proliferative activity was found during the first few days of the response. Elimination of the proliferating cells in this period caused a profound and longlasting suppression of the antibody formation in the marrow.