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Related Experiment Videos

Bacterial adhesion to uroepithelial cells: a morphologic study.

T J Marrie, J Lam, J W Costerton

    The Journal of Infectious Diseases
    |August 1, 1980
    PubMed
    Summary
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    Healthy and UTI patients' urine revealed bacteria use a surface matrix for adhesion to cells and each other. This finding is crucial for understanding urinary tract infections (UTI) and developing targeted treatments.

    Area of Science:

    • Microbiology
    • Urology
    • Cell Biology

    Background:

    • Urinary tract infections (UTI) are common, particularly in women.
    • Bacterial adhesion to uroepithelial cells is a key factor in UTI pathogenesis.
    • The role of bacterial surface structures in adhesion requires further elucidation.

    Purpose of the Study:

    • To investigate the in vivo bacterial adhesion mechanisms in healthy women and patients with UTI using electron microscopy.
    • To identify the role of the bacterial surface matrix in bacteria-host and bacteria-bacteria interactions.

    Main Methods:

    • Electron microscopy was used to examine urethral and midstream urine samples.
    • Samples were obtained from healthy women and patients with diagnosed urinary tract infections (UTI) and catheter-associated infections.

    Related Experiment Videos

  • Ruthenium red staining was employed to visualize the bacterial surface matrix.

    • Main Results:

    • Healthy subjects' urethral urine showed bacteria with a ruthenium red-positive fibrous matrix adhering to uroepithelial cells.
    • UTI patients' samples exhibited distinct bacterial microcolonies on uroepithelial cells, with varying bacterial morphology and arrangement.
    • Catheter-associated infections showed fewer uroepithelial cells and two distinct types of bacterial microcolonies.

    Conclusions:

    • The bacterial surface matrix plays a significant role in the adhesion of bacteria to uroepithelial cells.
    • This matrix is also involved in bacteria-bacteria adhesion, contributing to microcolony formation.
    • Understanding these adhesion mechanisms can inform strategies for preventing and treating UTIs.