[Characteristics of lipoprotein metabolism impairments in nephrotic syndrome]

Hyperlipoproteinemia corresponding to the IIb type was developed in the most patients with diffuse chronic glomerulonephritis and nephrotic syndrome. In blood concentration of very low density lipoproteins (VLDL) was increased with simultaneous accumulation of cholesterol in the fraction. Under conditions of nephrotic syndrome most distinct increase of the Sf 20-12 fraction and content of triglycerides, as compared with the Sf 12-0 fraction, was found in lipoproteins of low density (LDL) Content of cholesterol in high density lipoproteins (HDL) was decreased as compared with donor blood. Activity of postheparin lipoprotein lipase decreased in the most patients. Inspite of cholesterol accumulation in VLDL, triglycerides containing in the Sf 400-100 fraction of the patients were hydrolyzed by rat lipoprotein lipase at the high rate; hence, alteration of VLDL composition should be considered as a factor responsible for impairment of lipoprotein metabolism in blood. Content of VLDL was increased in blood of the patients within the first week of dexamethasone treatment. Within the subsequent period the hormone exhibited distinct hypolipidemic effect. In presence of the hormone heparin-dependent lipoprotein lipase was activated. Increase of lipolytic activity was observed in urine of patients simultaneously with distinct proteinuria.