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Relationship between chemical structure and allergenicity: aromatic amines
Dermatosen in Beruf Und Umwelt. Occupation and Environment
|January 1, 1983
Abstract:
This review utilizes current clinical and experimental contact sensitization data with aromatic amines to hypothesize on the relationship between chemical structure and allergenicity. The available data suggests: 1. A Primary amino group in the ring induces sensitizing properties; 2. aromatic amine allergenicity is related to basicity, resulting from the action of substituents in the ring; 3. electron donor substituents enhance whereas electron acceptor substituents attenuate the activity.