Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Local recurrence after amputation for osteosarcoma.

M Campanacci, M Laus

    The Journal of Bone and Joint Surgery. British Volume
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    MicroRNA in Sjögren's Syndrome: Their Potential Roles in Pathogenesis and Diagnosis.

    Journal of immunology research·2018
    Same author

    Can the onset of orbital cancer be the result of a prosthetic eye?

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2017
    Same author

    Subtotal and total femoral resection: an alternative to total femoral prosthetic replacement.

    International orthopaedics·2016
    Same author

    Neutral wetting brush layers for block copolymer thin films using homopolymer blends processed at high temperatures.

    Nanotechnology·2015
    Same author

    High aspect ratio PS-b-PMMA block copolymer masks for lithographic applications.

    ACS applied materials & interfaces·2014
    Same author

    Rapid thermal processing of self-assembling block copolymer thin films.

    Nanotechnology·2013
    Same journal

    Comorbidities in Perthes' disease: a case control study using the General Practice Research database.

    The Journal of bone and joint surgery. British volume·2012
    Same journal

    The treatment of complex tibial shaft fractures by the Ilizarov method.

    The Journal of bone and joint surgery. British volume·2012
    Same journal

    Posterior spinal arthrodesis for adolescent idiopathic scoliosis using pedicle screw instrumentation: does a bilateral or unilateral screw technique affect surgical outcome?

    The Journal of bone and joint surgery. British volume·2012
    Same journal

    Anterior deltoid deficiency in reverse total shoulder replacement: a biomechanical study with cadavers.

    The Journal of bone and joint surgery. British volume·2012
    Same journal

    Long-term results of dorsal intercarpal ligament capsulodesis for the treatment of chronic scapholunate instability.

    The Journal of bone and joint surgery. British volume·2012
    Same journal

    Medial patellofemoral ligament reconstruction for patellar instability in patients with hypermobility: a case control study.

    The Journal of bone and joint surgery. British volume·2012
    See all related articles

    Local recurrence after osteosarcoma surgery is a significant concern, occurring in 5.2% of cases. Careful surgical planning is crucial to prevent tumor regrowth at the amputation site.

    Area of Science:

    • Orthopedic Oncology
    • Surgical Pathology

    Background:

    • High-grade central osteosarcomas are aggressive bone tumors requiring surgical intervention.
    • Amputation or disarticulation is a common treatment for these tumors.
    • Local recurrence remains a challenge in osteosarcoma management.

    Purpose of the Study:

    • To analyze the incidence and causes of local recurrence following surgical treatment of high-grade central osteosarcomas.
    • To evaluate the effectiveness of adjuvant chemotherapy on local recurrence rates.
    • To discuss optimal management strategies for local osteosarcoma recurrences.

    Main Methods:

    • Retrospective analysis of 248 cases of high-grade central osteosarcoma treated with amputation or disarticulation.
    • Identification and categorization of factors contributing to local tumor recurrence.

    Related Experiment Videos

  • Review of treatment outcomes for local recurrences, including surgery, irradiation, and chemotherapy.

    • Main Results:

    • Local recurrence was observed in 5.2% of patients treated with amputation or disarticulation.
    • Identified causes include inadequate amputation level, unrecognized intramedullary extension, tumor seeding during biopsy or resection, extensive primary tumors, skip metastases, and iatrogenic implantation.
    • Adjuvant chemotherapy did not significantly alter the frequency of local recurrences.
    • Treatment of local recurrences via radical surgery or irradiation yielded poor prognoses.

    Conclusions:

    • Meticulous surgical technique and consideration of potential recurrence factors are paramount in primary osteosarcoma treatment.
    • Local recurrences of osteosarcoma carry a poor prognosis and necessitate aggressive management.
    • While adjuvant chemotherapy may play a role, it has not proven effective in preventing local recurrences in this study.