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Population data on two new HLA-D determinants, EI and RE

H Grosse-Wilde, G Hauptmann, R Johannsen

    Scandinavian Journal of Immunology
    |January 1, 1977
    PubMed
    Summary

    Two novel Human Leukocyte Antigen-D (HLA-D) determinants, EI and RE, were identified and characterized. These new HLA-D alleles show significant associations with specific HLA-B alleles, supporting their classification within the HLA-D series.

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    Area of Science:

    • Immunogenetics
    • Molecular Biology
    • Human Leukocyte Antigen (HLA) System

    Background:

    • The Human Leukocyte Antigen (HLA) system plays a crucial role in immune response and transplantation.
    • Identifying novel HLA alleles is essential for understanding immune diversity and improving tissue matching.

    Purpose of the Study:

    • To describe two newly identified HLA-D determinants, designated EI and RE.
    • To determine the phenotype frequencies and linkage disequilibrium of these novel HLA-D alleles.

    Main Methods:

    • Utilized Homozygous Typing Cells (HTC) for the characterization of new HLA-D determinants.
    • Performed HLA-D typing on over 300 unrelated individuals.
    • Calculated linkage disequilibrium parameters by simultaneously typing for HLA-A and -B alleles.

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    Main Results:

    • Phenotype frequencies for HLA-D EI and RE were determined as 0.045 and 0.098, respectively.
    • Significant statistical associations were found between HLA-D EI and HLA-B13/Bw17.
    • HLA-D RE demonstrated a significant association with HLA-Bw40.

    Conclusions:

    • The findings support the hypothesis that EI and RE represent new alleles within the HLA-D series.
    • The identified associations provide insights into the genetic linkage within the HLA complex.
    • These novel HLA-D alleles contribute to the expanding knowledge of HLA polymorphism.