LH and prolactin in estrogenized female rats: response to LHRH

Eighty day old female rats postnatally treated with estradiol benzoate (EB) show hyperprolactinemia and increased levels of LH with a positive correlation LH-prolactin, unlike the control animals. Fourteen days after ovariectomy this correlation disappears and the prolactin levels remain higher than control. On the contrary, the increase in LH levels is smaller in the EB group. The administration of LHRH to ovariectomized EB rats produces a decrease in prolactin levels, unobserved in the control group, as well as lower LH levels.