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Advances in protein sequencing

K A Walsh, L H Ericsson, D C Parmelee

Annual Review of Biochemistry

|January 1, 1981

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Protein analysis techniques have advanced significantly, enabling the solution of virtually any protein sequence. Future interplay between chemists and crystallographers promises deeper understanding of protein chemistry.

Area of Science:

Biochemistry
Structural Biology
Proteomics

Background:

The field of protein analysis has seen rapid advancements.
Understanding protein structure and function is crucial in molecular biology.

Purpose of the Study:

To review and highlight key procedures and strategies in modern protein analysis.
To discuss the increasing scope, efficiency, and sensitivity of protein sequencing methods.

Main Methods:

Review of diverse analytical techniques for protein sequence determination.
Focus on strategies with a bias toward familiar examples.

Main Results:

Significant improvements in the scope, efficiency, and sensitivity of protein analyses.

Related Experiment Videos

The capability to solve virtually any protein sequence is now achievable.

Conclusions:

The diversity of tactics in protein analysis enhances research capabilities.
Interdisciplinary collaboration between sequence chemists, crystallographers, and sequencing groups will advance the understanding of protein chemistry.