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[Cellular reactions of increased delayed sensitivity in human pseudotuberculosis]

N F Timchenko, M F Dzadzieva, V P Malyĭ

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 1, 1982
    PubMed

    Insights

    Far Eastern scarlatiniform fever triggers a specific cellular immunity transformation, manifesting as a delayed-type hypersensitivity reaction. Immunological tests accurately diagnose this condition, proving specific, sensitive, and simple for clinical use.

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Clinical Diagnostics

    Background:

    • Far Eastern scarlatiniform fever is a distinct febrile illness.
    • Understanding the immune response is crucial for diagnosis and management.
    • Previous diagnostic methods may lack specificity or sensitivity.

    Purpose of the Study:

    • To investigate the cellular immunity system's response in patients with Far Eastern scarlatiniform fever.
    • To evaluate the diagnostic utility of specific immunological tests for this condition.

    Main Methods:

    • Utilized Fradkin's neutrophil damage test, capillary cell migration inhibition test, and intradermal testing.
    • Examined 145 patients with Far Eastern scarlatiniform fever, 99 healthy controls, and 54 patients with other diseases.

    Main Results:

    • Demonstrated a specific transformation in the cellular immunity system associated with Far Eastern scarlatiniform fever.
    • Identified this transformation as a delayed-type hypersensitivity reaction.
    • Confirmed the specificity and high sensitivity of the employed immunological tests.

    Conclusions:

    • Far Eastern scarlatiniform fever induces a characteristic delayed-type hypersensitivity response.
    • The tested immunological methods are effective, specific, sensitive, and simple for diagnosing Far Eastern scarlatiniform fever.

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