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Spontaneous development of hyperprolactinaemia

H K Rjosk, R Fahlbusch, K von Werder

    Acta Endocrinologica
    |July 1, 1982
    PubMed
    Summary
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    This study investigated prolactin levels in hyperprolactinemic females, finding that prolactinomas generally exhibit limited growth potential. This insight is crucial for managing patients with hyperprolactinemia.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Oncology

    Background:

    • Hyperprolactinemia, characterized by elevated prolactin levels, can stem from various causes, including prolactin-secreting pituitary tumors (prolactinomas).
    • Understanding the natural history and growth potential of prolactinomas is essential for effective patient management and treatment strategies.

    Purpose of the Study:

    • To investigate the spontaneous development and progression of hyperprolactinemia and prolactinomas.
    • To assess the growth potential of prolactinomas in different clinical scenarios.

    Main Methods:

    • Longitudinal measurement of serum prolactin levels in hyperprolactinemic females.
    • Categorization of patients based on sella turcica imaging (normal, microprolactinoma, macroprolactinoma) and post-surgical status.

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  • Radiological and histological assessment of prolactinomas.

    • Main Results:

    • In most patients (69/71), prolactin levels remained stable or decreased over up to 6 years.
    • One patient developed a microprolactinoma with increasing prolactin levels.
    • One patient with a macroprolactinoma experienced tumor growth with elevated human prolactin (hPrl) levels.
    • One patient showed increased hPrl levels post-surgery without radiological changes.

    Conclusions:

    • Prolactinomas typically demonstrate limited spontaneous growth potential.
    • This characteristic should be a key consideration in the clinical management of hyperprolactinemic patients.
    • Further research may elucidate factors influencing prolactinoma growth dynamics.