[Reese's conjunctival melanosis. Two anatomicoclinical observations with ultrastructural study in one case]

Area of Science:

• Ophthalmology
• Dermatopathology
• Oncology

Background:

• Reese's conjunctival melanosis is a rare condition characterized by conjunctival pigmentation.
• Early detection and accurate diagnosis are crucial for managing potential malignant transformation.

Observation:

• Two cases of Reese's conjunctival melanosis are presented in middle-aged women.
• One patient exhibited diffuse pigmentation with a raised lesion at the sclerocorneal junction.
• The second patient had a long history of stable pigmentation that later developed into a malignant melanoma.

Findings:

• Histopathology confirmed coexisting atypical melanocytic hyperplasia, intraepithelial melanoma, and invasive melanoma in the first case.
• The second case progressed to a poorly differentiated epithelioid cell malignant melanoma.
• Ultrastructural study was performed on the invasive melanoma component.

Implications:

• These cases highlight the spectrum of Reese's conjunctival melanosis, from benign to malignant.
• Emphasizes the importance of vigilant monitoring for any changes in conjunctival pigmentation.
• Accurate histological and ultrastructural analysis is vital for diagnosis and treatment planning.