Kyrle's disease. Response to high-dose vitamin A

A 60-year-old man with a twelve-year history of Kyrle's disease is presented. Twice during this period, hospitalization and a variety of topical and systemic medications had resulted in little improvement. Recently, following the confirmation of the diagnosis, megadose vitamin A orally resulted in the resolution of most of the lesions. The amount of vitamin A was gradually reduced, and therapy was continued with a combination of vitamin A and vitamin E (dl-alpha-tocopheryl acetate).