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Related Experiment Videos

Cell motility in fibroblast aggregates

M T Armstrong, P B Armstrong

    Journal of Cell Science
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Contact inhibition of motility helps immobilize cells within tissues, maintaining organismal stability. Fibroblasts showed limited migration in 3D tissue masses compared to cell cultures.

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    Area of Science:

    • Cell Biology
    • Developmental Biology
    • Tissue Engineering

    Background:

    • Stable tissue and organ structures depend on cell confinement.
    • Contact inhibition of motility is a proposed mechanism for immobilizing cells.

    Purpose of the Study:

    • To evaluate the efficacy of contact inhibition in immobilizing cells within 3D tissue-like structures.
    • To quantify cell migration across interfaces in fused cell aggregates.

    Main Methods:

    • Spherical aggregates of chick fibroblasts (heart, sclera, skin) were prepared.
    • Aggregates were labeled with tritiated thymidine and fused with unlabeled aggregates of the same cell type.
    • Cell migration across the interface in fused aggregates was measured.

    Main Results:

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    • Fused aggregates formed a single mass with a planar interface.
    • Fibroblasts migrated across the interface into unlabeled aggregates.
    • In 3D masses, fibroblasts moved up to 17 cell diameters, significantly less than in monolayer culture.

    Conclusions:

    • Contact inhibition of motility effectively limits cell migration in 3D tissue-like environments.
    • This mechanism contributes to positional stability of cells within tissues and organs.