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[Dynamics of changes in halo-forming cells during pathologic processes]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|February 1, 1981
Summary
A new method detects halo-forming cells (HFC) in blood. These cells appear before antibody-producing cells and are not reliant on immunological components for halo formation.
Area of Science:
- Immunology
- Cell Biology
Background:
- Halo-forming cells (HFC) are observed in peripheral blood.
- The immunological basis of halo formation is not fully understood.
Purpose of the Study:
- To describe a method for detecting halo-forming cells (HFC) in peripheral blood.
- To characterize the temporal changes in HFC numbers.
- To investigate the immunological basis of the halo formation process.
Main Methods:
- Detection of halo-forming cells (HFC) in peripheral blood.
- Analysis of the time course of HFC number changes.
Main Results:
- A method for detecting HFC in peripheral blood is presented.
- Data on the time course of HFC numbers are provided.
- Halo formation was found to be independent of immunological components like complement, antigens, or hemolyzing antibodies.
- HFC were observed in peripheral blood preceding the appearance of antibody-producing cells (plaque-forming cells).
Conclusions:
- The described method allows for HFC detection in peripheral blood.
- Halo formation is a non-immunological process.
- HFC appear in circulation earlier than plaque-forming cells, suggesting a distinct role in immune responses.