[Hypoxia-hypercapnic effects on lactate dehydrogenase activity in rat heart tissue]

Activity of lastate dehydrogenase (LDH) was studied in blood and tissues of left and right rat heart ventricles after the simultaneous effect of hypoxia and hypercapnia. The animals were kept in the closed space, where content of gases to the end of the experiment (about 1.5 hr) was equal to: O2--10%, CO2--3%. Activity of LDH was decreased within the first 3 days and the maximal enzymatic activity was observed within 15 days; after 30 days of hypoxic-hypercapnic exposure activity of LDH was significantly decreased in myocardium but it reached the control value in the serum of blood obtained from the heart.