Related Experiment Video
Updated: Jul 28, 2026

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect
Published on: June 14, 2015
[Hemodynamic control by optimization of the cardiac pump]
Abstract:
Transport of energy appears as the ultimate finality of the force convection cardiovascular system. Blood pressure cardiac output and vascular resistances are the three major components of the circulatory system. Among them, blood pressure is regarded as the regulated parameter whose control value is the best adapted parameter, to each kind of activity, neurogenic mechanisms. The authors, considering the physiological variations of blood pressure during increasing energetic loads imposed on the organism, propose a new control function: optimization of cardiac mechanical power necessary to assure convection of the energy needed by the organism. Blood pressure is no more regarded as a constant. Simultaneous changes in cardiac output and blood pressure are both significant, adjusted to realize energetic minimisation of the cardiac pump. This cardiovascular regulation is described by a system of equations whose resolution leads to results in good accordance with physiological data.
More Related Videos
Related Concept Videos
Pathophysiology of Cardiac Performance
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Heart Failure V: Medical Management

