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Compliance differences following administration of theophylline at six- and twelve-hour intervals
Annals of Allergy
|May 1, 1980
Insights
Pediatric patients showed better adherence to theophylline when using sustained-release tablets compared to short-acting formulations, regardless of dosing interval.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Clinical Pharmacy
Background:
- Theophylline is a medication used to treat respiratory diseases in children.
- Optimizing medication compliance is crucial for effective treatment outcomes in pediatric populations.
- Understanding dosing interval effects on compliance is important for improving therapeutic efficacy.
Purpose of the Study:
- To compare medication compliance between six- and 12-hour dosing intervals for theophylline.
- To evaluate the impact of different theophylline formulations (sustained-release vs. short-acting) on compliance in pediatric outpatients.
Main Methods:
- A comparative study design was employed.
- Compliance was assessed in a pediatric outpatient setting.
- Theophylline administration at six-hour and 12-hour intervals was evaluated.
Main Results:
- Compliance was statistically higher with sustained-release theophylline tablets compared to short-acting tablets.
- The dosing interval (six- vs. 12-hour) did not show a statistically significant difference in compliance when controlling for formulation.
Conclusions:
- Sustained-release theophylline formulations improve medication compliance in pediatric outpatients.
- Optimizing theophylline formulation is a key strategy for enhancing adherence in pediatric care.
- Further research could explore patient-specific factors influencing compliance with theophylline therapy.
Abstract:
This study evaluated the compliance differences between administration of theophylline at six- and 12-hour intervals in a pediatric outpatient population. Compliance was statistically better with the sustained release tablets than with the short acting tablets.