Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stoichiometric model of alpha-cyclodextrin complex formation

T W Rosanske, K A Connors

    Journal of Pharmaceutical Sciences
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparisons of PNEC derivation logic flows under example regulatory schemes and implications for ecoTTC.

    Regulatory toxicology and pharmacology : RTP·2021
    Same author

    Aromatic hydroxylation as an analytical reaction.

    Analytical chemistry·2012
    Same author

    Statistical properties of thermodynamic quantities for cyclodextrin complex formation.

    Journal of pharmaceutical sciences·2000
    Same author

    Binding of substituted acetic acids to alpha-cyclodextrin in aqueous solution.

    Journal of pharmaceutical sciences·1997
    Same author

    Binding of cyclodextrins to alicyclic and aromatic substrates: complex formation of alpha-, beta-, and gamma-cyclodextrins with substituted cyclohexanecarboxylic acids and phenylalkanoic acids.

    Journal of pharmaceutical sciences·1997
    Same author

    Prediction of binding constants of alpha-cyclodextrin complexes.

    Journal of pharmaceutical sciences·1996
    Same journal

    Immune tolerance platforms to mitigate unwanted immune responses.

    Journal of pharmaceutical sciences·2026
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    See all related articles

    Alpha-cyclodextrin forms complexes with cinnamic acid derivatives. Stability constants vary, with higher values for substrates having lower dipole moments, indicating complex formation is influenced by molecular properties.

    Area of Science:

    • Supramolecular Chemistry
    • Physical Organic Chemistry

    Background:

    • Cyclodextrins are widely studied for their ability to form inclusion complexes.
    • Understanding host-guest interactions is crucial for applications in drug delivery and molecular recognition.

    Purpose of the Study:

    • To investigate the complexation of alpha-cyclodextrin with three different substrates: 3,5-dimethoxycinnamic acid, benzalacetone, and methyl cinnamate.
    • To determine the stoichiometry and stability constants of these host-guest complexes using various analytical methods.

    Main Methods:

    • Solubility studies
    • Spectroscopic techniques (UV-Vis, fluorescence)
    • Kinetic measurements
    • Analysis of stability constants (K11, K12)

    Related Experiment Videos

    Main Results:

    • Stability constants (K11) ranged from 105 M⁻¹ (benzalacetone) to 1965 M⁻¹ (3,5-dimethoxycinnamic acid).
    • Complex formation stoichiometry varied, with some systems forming 1:1 and others 1:2 complexes (SL and SL2).
    • A negative correlation was observed between substrate dipole moment and complex stability constants.

    Conclusions:

    • The study elucidates the complexation behavior of alpha-cyclodextrin with substituted cinnamic acid derivatives.
    • The findings suggest that the dipole moment of the substrate plays a significant role in determining the stability of the formed inclusion complexes.
    • A model for complex formation was proposed, accounting for observed stoichiometries and isomeric complexes.