An automated electrochemical method for in vivo monitoring of catecholamine release

A computer-controlled electrochemical system for the in vivo monitoring of catecholamines and their metabolites is described. The system is composed of a microcomputer, real time interface board, and a commercial electrochemical instrument. The method and theory of the electrochemical technique are explained and details concerning the construction of the electrodes are given. Descriptions of the hardware and software are also provided. Experimental results are presented to demonstrate the use of the system for long-term in vivo monitoring and for detecting the change in the level of oxidizable species after amphetamine administration.