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A possible hemoglobin marker of alcoholism
Advances in Experimental Medicine and Biology
|January 1, 1980
Abstract:
Human erythrocytes were found to synthesize 5-deoxy-D-xylulose-1-phosphate from added acetaldehyde and endogenous dihydroxyacetone phosphate. In separate experiments 5-deoxy-D-xylulose-1-phosphate was observed to react with hemoglobin Ao, forming a stable adduct. Formation and accumulation of this unique form of hemoglobin in the blood of alcohol users, by integrating the blood acetaldehyde concentration, would provide a dose-time record of alcohol consumption.