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Updated: Aug 15, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
Published on: March 3, 2016
[Structural characteristics of the centromeric heterochromatin of mice]
Abstract:
The ultrastructure of centromeric heterochromatin in the interphase nuclei and mitotic chromosomes has been studied. The centromeric heterochromatin always consists of 10 nm DPN fibrils tightly arranged in a block having no chromonemal level of organization. Chromosome arms contain 20 nm DPN fibrils able to produce chromonemal structures in the prophase and telophase chromosomes of the normal mitosis, and in the metaphase chromosomes after experimental recondensation. The condensed chromatin of chromosome arms in the mitosis and interphase nuclei is less resistant to the dispersing action of hypotonic solutions compared to the centromeric heterochromatin.
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