[Method of evaluating the functional activity of viral antigens]

A method for evaluation of the functional activity of viral antigens in their interaction with antibodies, has been developed. The proposed index of the functional activity is the quantitative characteristic of the neutralization process as a whole. The results obtained with this method correspond to those of the seroepidemiologic test: the diagnostic agents prepared from tick-borne encephalitis virus strains and clones, known as functionally active, showed greater activity in comparison with the reference strain. The proposed method can be used for the determination of the functional activity of viral antigens in different serologic tests.