Bioavailability and multiple dose characteristics of a new sustained release theophylline tablet

Bioavailability and theophylline level variability were compared between a standard theophylline elixir and a new sustained release theophylline tablet. The results demonstrate a good bioavailability and a reduced dosage interval with less theophylline level variability for the sustained release tablet, administered every 12 hours, than with the immediate release product, every six hours.