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Mouse hepatitis virus and herpes simplex virus move along different CNS pathways
S Perlman1, E Barnett, G Jacobsen
1Department of Pediatrics, College of Dentistry, University of Iowa, Iowa City 52242.
Advances in Experimental Medicine and Biology
|January 1, 1993
Summary
Mouse hepatitis virus and herpes simplex virus type 1 infect different neural pathways in the olfactory bulb. These viruses can help researchers study olfactory bulb neuroanatomy and function.
Area of Science:
- Neuroscience
- Virology
- Neuroanatomy
Background:
- The olfactory bulb is a key brain region for processing smell.
- Understanding its complex neural connections is crucial for neuroscience research.
Purpose of the Study:
- To investigate the spread and infection patterns of mouse hepatitis virus (JHM strain) and herpes simplex virus type 1 within the central nervous system.
- To determine if these viruses can be used as tools to map olfactory bulb neuroanatomy.
Main Methods:
- Inoculation of viruses into the nares and main olfactory bulb of model organisms.
- Examination of viral spread and infection sites within the central nervous system.
Main Results:
- Both mouse hepatitis virus and herpes simplex virus type 1 infected distinct subsets of olfactory bulb connections.
- The infection patterns of the two viruses were different, indicating selective targeting of neural pathways.
Conclusions:
- Mouse hepatitis virus and herpes simplex virus type 1 are valuable tools for dissecting the neuroanatomic connections of the olfactory bulb.
- These viruses may also facilitate functional studies of the olfactory system.