Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

5.8K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.8K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.5K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.5K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

34
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
34
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

35
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
35
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

33
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
33

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of a Fully Automated Hybrid Deep Learning Cardiac Substructure Segmentation Tool for Contouring and Dose Evaluation in Lung Cancer Radiotherapy.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023
Same author

First Report of Squash leaf curl virus in Cucurbits in Lebanon.

Plant disease·2019
Same author

First Report of Watermelon chlorotic stunt virus in Cucurbits in Lebanon.

Plant disease·2019
Same author

Dual-hormone artificial pancreas: benefits and limitations compared with single-hormone systems.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Extreme tuning of wetting on 1D nanostructures: from a superhydrophilic to a perfect hydrophobic surface.

Nanoscale·2017
Same author

Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report.

Gut·2016

Related Experiment Video

Updated: May 3, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

16.5K

Adhesion molecules in inflammatory bowel disease

S C Jones1, R E Banks, A Haidar

  • 1Centre for Digestive Diseases, General Infirmary, Leeds.

Gut
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Soluble adhesion molecules like VCAM-1 and ICAM-1 are elevated in inflammatory bowel diseases, indicating local upregulation and potential roles in leucocyte migration. Their levels decrease with treatment, suggesting therapeutic targets.

More Related Videos

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

7.2K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

9.2K

Related Experiment Videos

Last Updated: May 3, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

16.5K
Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

7.2K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

9.2K

Area of Science:

  • Immunology
  • Gastroenterology
  • Biochemistry

Background:

  • Leukocyte adhesion to endothelium is crucial for migration to inflammatory sites.
  • Soluble adhesion molecules, including ICAM-1, E selectin, and VCAM-1, are released from cell surfaces and detectable in serum.
  • Understanding these molecules' roles in inflammatory bowel disease (IBD) is vital.

Purpose of the Study:

  • To investigate serum concentrations and tissue expression of ICAM-1, E selectin, and VCAM-1 in patients with Crohn's disease and ulcerative colitis.
  • To correlate these adhesion molecule levels with disease activity and treatment response.

Main Methods:

  • Serum samples from active and inactive IBD patients and healthy controls were analyzed for ICAM-1, E selectin, and VCAM-1.
  • Tissue expression of these molecules was assessed using immunohistology.
  • Samples were collected pre-treatment, during treatment, and post-remission.

Main Results:

  • Circulating VCAM-1 was significantly higher in active ulcerative colitis than inactive disease or controls.
  • Active Crohn's disease patients showed higher ICAM-1 levels than controls.
  • VCAM-1 and ICAM-1 levels decreased significantly with treatment and remission in respective diseases.
  • Increased ICAM-1 and E selectin expression was observed in inflamed IBD tissues.

Conclusions:

  • Elevated circulating adhesion molecules are associated with IBD.
  • Evidence suggests local upregulation of ICAM-1 in inflamed tissues.
  • Adhesion molecule expression may initiate leukocyte migration and local inflammation; circulating forms might modulate adhesion.