Related Experiment Videos
[Nd:YAG laser surgery in treatment of allergic rhinitis]
1Hals-, Nasen-, Ohrenklinik mit Polikliniken, Klinikum Benjamin Franklin, Freie Universität Berlin.
Abstract:
The purpose of our study was to evaluate the effects of laser turbinectomy on local allergic inflammation by measuring the secretion of mediators (histamine, bradykinin, and TAME-esterase activity) in nasal lavage fluid after nasal provocation with different allergen concentrations. Our study included fifteen patients, aged fifteen to 35, who displayed perennial house-dust-mite rhinitis (positive prick test, RAST class > 2 and positive nasal provocation with Dermatophagoides pteronyssinus [D.p.] extract) and hypertrophic inferior turbinates. Rhinomanometry (Rhino-Test 441, Allergopharma, Reinbeck, Germany) and nasal provocation with D.p. extract (Allergopharma, Germany) followed by lavage were performed in all patients. The procedure was repeated three and twelve months after neodymium:YAG laser turbinectomy. Three and twelve months after laser turbinectomy, we found a significant improvement of nasal flow (p < 0.01, p < 0.05) and resistance (p < 0.01, p < 0.01) but no change of mediator levels in nasal lavage after allergen provocation, suggesting that laser turbinectomy has no effects on local allergic inflammation.
Insights
Laser turbinectomy improved nasal airflow and reduced resistance in patients with house-dust-mite rhinitis. However, it did not affect local allergic inflammation markers in nasal lavage fluid.
Area of Science:
- Otorhinolaryngology
- Allergology
- Laser Surgery
Context:
- Perennial allergic rhinitis, particularly due to house-dust mites, often involves inferior turbinate hypertrophy.
- Assessing the impact of surgical interventions on underlying inflammatory processes is crucial for treatment efficacy.
Purpose:
- To investigate the effect of neodymium:YAG laser turbinectomy on local allergic inflammation in patients with perennial house-dust-mite rhinitis.
- To measure mediator levels (histamine, bradykinin, TAME-esterase activity) in nasal lavage fluid following allergen challenge post-procedure.
Summary:
- Fifteen patients with diagnosed house-dust-mite rhinitis and turbinate hypertrophy underwent laser turbinectomy.
- Nasal airflow and resistance significantly improved at three and twelve months post-surgery.
- No significant changes were observed in histamine, bradykinin, or TAME-esterase activity in nasal lavage fluid after allergen provocation.
Impact:
- Laser turbinectomy effectively improves nasal airflow and reduces resistance in patients with allergic rhinitis and turbinate hypertrophy.
- The procedure does not appear to modulate the local allergic inflammatory response as measured by mediator secretion.