Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Theoretical model for water diffusion in tissues

A Szafer1, J Zhong, J C Gore

  • 1Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.

Magnetic Resonance in Medicine
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nature and interpretation of BOLD signals in white matter - A review.

Magnetic resonance imaging·2025
Same author

Tissue sodium content in patients with systemic lupus erythematosus: association with disease activity and markers of inflammation.

Lupus·2020
Same author

Search for contact interactions and large extra dimensions in the dilepton channel using proton-proton collisions at [Formula: see text] 8 TeV with the ATLAS detector.

The European physical journal. C, Particles and fields·2015
Same author

A measurement of the ratio of the production cross sections for [Formula: see text] and [Formula: see text] bosons in association with jets with the ATLAS detector.

The European physical journal. C, Particles and fields·2015
Same author

Measurement of distributions sensitive to the underlying event in inclusive Z-boson production in [Formula: see text] collisions at [Formula: see text] TeV with the ATLAS detector.

The European physical journal. C, Particles and fields·2015
Same author

Search for Scalar Charm Quark Pair Production in pp Collisions at sqrt[s]=8  TeV with the ATLAS Detector.

Physical review letters·2015
Same journal

Feasibility and SNR Performance of Hyperpolarized <sup>129</sup>Xe Gas Exchange Imaging Using a Balanced SSFP Sequence.

Magnetic resonance in medicine·2026
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
See all related articles

This study models water diffusion in tissues, finding that apparent diffusion coefficients (ADC) differ from standard formulas. Changes in brain tissue diffusion after ischemia likely stem from altered cell volume and diffusion within cells, not just membrane permeability.

Area of Science:

  • Biophysics
  • Medical Imaging
  • Computational Biology

Background:

  • Water diffusion in biological tissues is crucial for understanding tissue properties and disease states.
  • Existing models for apparent diffusion coefficients (ADC) may not fully capture complex tissue microstructures.

Purpose of the Study:

  • To analytically and numerically investigate water diffusion in a detailed tissue model.
  • To derive expressions for ADC in various tissue types and compare them with simulations.
  • To analyze the impact of intracellular/extracellular differences and T2 relaxation times on ADC measurements, particularly in the context of brain ischemia.

Main Methods:

  • Developed an analytical model of tissue as periodic cells with permeable membranes in an extracellular medium.
  • Performed Monte Carlo simulations to validate derived expressions for ADC.

Related Experiment Videos

  • Investigated the influence of differing intracellular and extracellular diffusion coefficients and T2 relaxation times.

    • Main Results:

    • Derived expressions for ADC in isotropic and nonisotropic tissues.
    • Demonstrated that calculated ADCs deviate from the widely used "fast exchange" formula.
    • Showed that observed changes in brain tissue ADC after ischemia are unlikely due to reduced membrane permeability alone.

    Conclusions:

    • Membrane properties significantly influence ADC, but changes in brain tissue diffusion post-ischemia are more likely attributed to alterations in cellular volume fraction and intracellular/extracellular diffusion rates.
    • The study highlights limitations of the "fast exchange" model for complex tissue diffusion analysis.