[NSAID-induced hepatotoxicity: aceclofenac and diclofenac]

Diclofenac (Voltaren, Geigy) and aceclofenac (Falcol, Bayer) belong to a chemical subgroup of nonsteroidal antiinflammatory drugs (NSAID) that are arylalkanoic groups of phenylacetic acid. Hepatotoxicity has been reported with the majority of NSAID although its incidence is not known. We describe two patients who presented hepatic injury after diclofenac and aceclofenac therapy. Recognition of cholestasis associated with NSAID may prevent invasive investigations in jaundiced patients. Clinically liver injury associated with NSAID is not prevalent but we think it is interesting to report those patients for recognition of the role of certain risk factors and to suggest close monitoring.