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Related Experiment Videos

[Collagenous colitis and chronic diarrhea]

A Zaragoza Marcet1, P Meseguer García

  • 1Unidad de Digestivo, Servicio de Medicina Interna, Hospital Lluís Alcanyís, Xátiva, Valencia.

Revista Espanola De Enfermedades Digestivas
|August 1, 1996
PubMed
Summary
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Collagenous colitis, a cause of chronic watery diarrhea, requires colonoscopy with biopsies for diagnosis, even with a normal-appearing colon. Prednisone effectively treated a patient

Area of Science:

  • Gastroenterology and Internal Medicine
  • Colorectal Pathology

Context:

  • Chronic watery diarrhea presents a diagnostic challenge, often with normal initial investigations.
  • Collagenous colitis is an underrecognized cause of persistent diarrhea and weight loss.

Purpose:

  • To highlight the diagnostic utility of total colonoscopy with multiple biopsies in unexplained chronic diarrhea.
  • To emphasize that rectal biopsies alone are insufficient to rule out collagenous colitis.

Summary:

  • A 68-year-old woman with chronic watery diarrhea and weight loss was diagnosed with collagenous colitis via colonic biopsies, despite normal endoscopic appearance.
  • Initial treatment with mesalazine failed, but prednisone therapy led to symptom resolution.
  • Histological features persisted on follow-up, underscoring the chronic nature of the condition.

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Impact:

  • Stresses the importance of comprehensive colonoscopic evaluation for diagnosing collagenous colitis.
  • Recommends considering collagenous colitis in the differential diagnosis of chronic diarrhea.
  • Informs clinical practice regarding diagnostic strategies for unexplained chronic diarrhea.