Carotid plaque morphology: a review

The recent North American Symptomatic Carotid Endarterectomy Trial has answered fairly conclusively the questions concerning the optimal management of patients with symptoms who have a > 70% stenosis of the internal carotid artery. It has also had the effect of refocusing attention on carotid pathology. The main question still to be answered is whether surgical management is the optimum treatment for other groups of patients with carotid disease. From various studies done on the natural history of carotid plaques it is apparent that there are subgroups who may benefit from surgery, namely those who will progress to stroke if not treated. The problem comes in identifying these subgroups by the factors which cause them to progress. This paper aims to review the role that plaque morphology has in the development of symptoms and whether it should be included with degree of stenosis in assessing the risk of a carotid plaque. The non-invasive assessment of plaque morphology is also reviewed. The evidence from this review does not support the use of plaque morphology as a discriminating factor for carotid endarterectomy at present.