[A morphofunctional evaluation of the immunomodulating action of nitrosomethylurea]

The thymuses and spleens from healthy and tumor-bearing (leukemia P 388 and Lewis' carcinoma) were morphometrically studied after a single administration of the antitumor agent nitrosomethylurea in doses of 96 and 4 mg/kg. When used both in the high and low doses, nitrosomethylurea had an immunomodulating effect, causing the activation of cell-mediated immunity in healthy and tumor-bearing (in early malignancy) animals when given in the small dose.