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Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative
K Raghavan1, J K Buolamwini, M R Fesen
1Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Journal of Medicinal Chemistry
|March 17, 1995
Abstract:
We present the results from a comparative molecular field analysis (CoMFA) of a set of flavone analogs that inhibit HIV-1 integrase-mediated cleavage (3'-processing step) and integration (strand transfer step) in vitro. The results indicate a strong correlation between the inhibitory activity of these flavones and the steric and electrostatic fields around them. CoMFA quantitative structure-activity relationship models with considerable predictive ability (cross-validated r2 as high as 0.8) were obtained.