[Laboratory research of biomechanics assay of skin wound healing]

The study described skin wound healing process in mice in the field of biomechanics by assaying the wound breaking strength (WBS) at different time with the INSTRON 4300 Materials Tester (England). The result revealed there was no significant change of WBS on the 3rd and 4th days. From the 5th to 21st day the WBS increased rapidly. From the 21st to 28th day the increased of WBC became slow and after the 28th day WBS tended to be stable. By the day of seven, the healing wound strength was 14% of normal skin and by the day of 28 the strength was 80%. Histopathologic appearance manifested a gradual change process of wound from inflammation to fibril healing. By this we divided the wound healing process into three periods: adhesion period (1st to 4th day), fibril healing period (5th to 28th day) and fibril reconstructive period (after the 28th day). The study provided a clinical reference for the best times of removing sutures and taking functional exercise after an operation.