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Cutaneous mastocytosis complicating pregnancy
J G Donahue1, J B Lupton, A M Golichowski
1Department of Obstetrics and Gynecology, Indiana University Medical Center, Indianapolis, USA.
Obstetrics and Gynecology
|May 1, 1995
Summary
Telangiectasia macularis eruptiva perstans, a rare skin condition, can complicate pregnancy. Elevated histamine levels in patients with this condition may be linked to preterm labor risks.
Area of Science:
- Obstetrics and Gynecology
- Dermatology
- Hematology
Background:
- Telangiectasia macularis eruptiva perstans (TMEP) is a rare cutaneous mastocytosis variant.
- It is characterized by elevated histamine excretion.
- TMEP has not been previously documented during pregnancy.
Observation:
- A pregnant woman in her second trimester experienced an anaphylactoid reaction, rash, uterine contractions, and vaginal bleeding.
- Skin biopsy confirmed perivascular mast cell infiltration consistent with TMEP.
- Markedly elevated urinary histamine levels were detected.
Findings:
- The patient's symptoms suggested a link between TMEP and pregnancy complications.
- Successful treatment involved tocolytics and antihistamines.
- Elevated histamine excretion in TMEP may correlate with preterm labor.
Implications:
- This case highlights a potential obstetric risk associated with TMEP.
- Monitoring histamine levels in pregnant patients with TMEP is crucial.
- Early intervention may prevent adverse pregnancy outcomes.
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