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Related Experiment Videos

Melatonin receptors: are there multiple subtypes?

M L Dubocovich1

  • 1Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL 60611, USA.

Trends in Pharmacological Sciences
|February 1, 1995
PubMed
Summary
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Melatonin acts on multiple sites, with research identifying at least two receptor subtypes, ML1 and ML2. Advances in pharmacology and molecular biology aid in characterizing these melatonin receptors.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Endocrinology

Background:

  • Evidence suggests the hormone melatonin has multiple sites of action.
  • Recent pharmacological and molecular advances facilitate the characterization of melatonin receptor subtypes.

Purpose of the Study:

  • To discuss the properties of melatonin receptors.
  • To explain the basis for classifying melatonin receptors into at least two subtypes (ML1 and ML2).

Main Methods:

  • Development of novel melatonin receptor agonists and antagonists.
  • Use of high-affinity radioligands.
  • Application of quantitative bioassays.
  • Cloning of melatonin receptors.

Main Results:

Related Experiment Videos

  • Characterization of native and recombinant melatonin receptors is advancing.
  • Properties of melatonin receptors are being elucidated.
  • A basis for classifying receptors into at least two subtypes (ML1 and ML2) is established.

Conclusions:

  • Melatonin receptor research is progressing due to new pharmacological and molecular tools.
  • At least two melatonin receptor subtypes, ML1 and ML2, have been identified.