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[Deoxycorticosterone-producing adrenocortical carcinoma--a case report]

H Furuse¹, H Watase, H Ihara

¹Department of Urology, Hamamatsu University School of Medicine.

Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology

|April 1, 1995

Summary

A case of deoxycorticosterone (DOC)-producing adrenocortical carcinoma presenting with hematuria and hypokalemia is reported. Surgical removal normalized DOC levels and resolved symptoms, highlighting this rare tumor's presentation and management.

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Area of Science:

Endocrinology
Nephrology
Oncology

Background:

Adrenocortical carcinoma is a rare malignancy with diverse clinical presentations.
Deoxycorticosterone (DOC)-producing tumors are exceptionally rare subtypes, often associated with distinct hormonal imbalances.

Observation:

A 39-year-old male presented with gross hematuria, left lower abdominal discomfort, and hydronephrosis.
Imaging revealed a left renal mass, and endocrinological studies showed elevated serum deoxycorticosterone (DOC) levels without hypertension.
Laboratory data indicated hypokalemia, a potential indicator of mineralocorticoid excess.

Findings:

Pathological diagnosis confirmed adrenocortical carcinoma.
Post-surgical normalization of serum DOC and potassium levels confirmed the tumor as the source of hormone overproduction.

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The patient experienced an uneventful recovery and remained disease-free at 12-month follow-up.

Implications:

This case underscores the importance of considering rare hormone-secreting tumors in the differential diagnosis of renal masses with atypical presentations.
Early diagnosis and surgical resection are crucial for favorable outcomes in DOC-producing adrenocortical carcinoma.
Further research into the specific mechanisms and clinical management of DOC-producing adrenocortical tumors is warranted.