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[The adsorbed-DTP-m vaccination of children with allergically altered reactivity]
Insights
Adsorbed DPT-m vaccine with reduced antigen content is safe for children with allergic diseases, even during subacute phases. Antibody synthesis remains effective, allowing continued immunization safely.
Area of Science:
- Pediatrics
- Immunology
- Allergology
Background:
- Children with allergic diseases often require immunization.
- Standard DPT vaccines may pose risks for allergic individuals.
- Assessing the safety and efficacy of modified DPT vaccines in this population is crucial.
Purpose of the Study:
- To evaluate the safety and immunogenicity of adsorbed DPT-m vaccine with reduced antigen content in children with allergic diseases.
- To determine if reduced antigen load impacts antibody synthesis.
- To assess the feasibility of continuing immunization in allergic children, even during active or subacute disease phases.
Main Methods:
- Immunization and booster doses of adsorbed DPT-m vaccine administered to 45 and 15 children, respectively.
- Children had varying severities of allergic disease and received concurrent complex drug therapy.
- Monitoring for general, allergic, and neurological reactions post-vaccination.
Main Results:
- The post-vaccination period was generally favorable.
- Observed reactions did not prevent immunization continuation, except for neurological reactions.
- Reduced diphtheria and tetanus toxoid content did not impair specific antibody synthesis.
- The vaccine is usable during allergic disease remission and subacute phases.
Conclusions:
- Adsorbed DPT-m vaccine with reduced antigen content can be safely used in children with allergic diseases.
- This modified vaccine allows for continued immunization schedules even during subacute allergic conditions.
- The reduced antigen formulation maintains effective antibody production against diphtheria and tetanus.
Abstract:
Immunization and booster immunization with adsorbed DPT-m vaccine was carried out, respectively, in 45 and 15 children with different severity of the course of an allergic disease, each child receiving simultaneously individually prescribed complex drug therapy. The postvaccinal period took a relatively favorable course. General and allergic reactions and complications observed after the injection of the preparation did not hinder the continuation of the course of immunization, while the appearance of neurological reactions provoked doubts on the expediency of the repeated injection of this preparation. A decrease in the content of diphtheria and tetanus toxoids in one immunization dose did not lead to the decreased synthesis of specific antibodies. The present investigation showed the possibility of using adsorbed DPT-m vaccine with reduced antigen content in cases of both the remission of an allergic disease and the subacute course of such disease.