[Transitional cell carcinoma of bladder occurring during pregnancy: report of two patients]

Primary transitional cell carcinoma (TCC) of the bladder occurring during pregnancy is extremely rare and only 16 patients have been reported in the literature. Patient 1: A 24-year-old primigravida at 33 weeks of gestation presented with gross hematuria. Cystoscopy revealed a large bladder tumor. After delivery TUR-Bt was performed. Because of frequent reccurrences after TUR-Bt, radical cystectomy was done. Pathological study revealed transitional cell carcinoma, G1-G2, pTa. Patient 2: A 34-year-old gravida 11 at 6 weeks of gestation presented with gross hematuria. Cystoscopy revealed a papillary bladder tumor. TUR-Bt was performed after artificial abortion. Pathological study revealed papillary transitional cell carcinoma, G1 > G2, pTa. Eighteen patients of TCC of the bladder occurring during pregnancy were reviewed. Fifteen of the 18 patients presented with gross hematuria. All patients had superficial, solitary, grade 1 or 2 papillary TCC, except one grade 3 patient. Cystoscopy should be considered in all pregnant women with gross hematuria. Small TCCs of the bladder during pregnancy can be treated safely by TUR-Bt during pregnancy or after delivery.