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[Post-transfusion purpura]
P Weiner1, R Ganem, Y Schechter
1Medical Dept. A, Hillel Yaffe Medical Center, Hadera.
Post-transfusion purpura (PTP) is a rare syndrome that may develop a week after blood transfusion. In this syndrome, which occurs mainly in women, blood transfusion is followed by severe thrombocytopenia a week later. A 72-year-old woman with this syndrome is presented. High-dose intravenous gamma-globulin resulted in prompt resolution of her thrombocytopenia. The basic pathophysiologic mechanism of PTP is the development of an alloantibody to a human platelet antigen. The mystery of PTP is why the patients' own, as well as transfused PLA1-negative platelets, are destroyed.
Post-transfusion purpura (PTP) is a rare syndrome that may develop a week after blood transfusion. In this syndrome, which occurs mainly in women, blood transfusion is followed by severe thrombocytopenia a week later. A 72-year-old woman with this syndrome is presented. High-dose intravenous gamma-globulin resulted in prompt resolution of her thrombocytopenia. The basic pathophysiologic mechanism of PTP is the development of an alloantibody to a human platelet antigen. The mystery of PTP is why the patients' own, as well as transfused PLA1-negative platelets, are destroyed.