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Estrogen dermatitis
W B Shelley1, E D Shelley, N Y Talanin
1Department of Medicine, Medical College of Ohio, Toledo 43699.
Journal of the American Academy of Dermatology
|January 1, 1995
Summary
Women can develop estrogen dermatitis, a condition causing skin issues that worsen premenstrually. Diagnosis involves estrogen skin tests, and treatment includes antiestrogen therapy or eliminating oral estrogens.
Area of Science:
- Dermatology
- Endocrinology
- Immunology
Background:
- Autoimmune progesterone dermatitis presents with various skin reactions like pruritus and urticaria.
- Estrogen sensitivity in dermatological conditions was previously undescribed.
Observation:
- This study investigated hormone sensitization in women with premenstrual skin lesion flares.
- Skin tests were conducted using 18 hormones and control substances.
Findings:
- Seven women showed estrogen sensitivity, with premenstrual exacerbations of skin conditions.
- Positive intradermal estrogen skin tests, either urticarial or delayed-type, were observed.
- Antiestrogen therapy with tamoxifen and estrogen elimination were effective treatments.
Implications:
- Estrogen sensitization can occur in women, indicated by premenstrual worsening of skin problems.
- Estrogen dermatitis is a newly identified disorder diagnosed via intradermal estrogen skin tests.
- Tamoxifen offers a specific therapeutic option for estrogen dermatitis.