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[The clinico-bacteriological characteristics of urinary system infection in children]
Insights
This study examined 317 children with urinary tract infections, finding that Enterobacteriaceae, particularly Escherichia, were common. Bacterial antilysozyme activity correlated with pyelonephritis severity and course, indicating prognostic value.
Area of Science:
- Pediatrics
- Urology
- Microbiology
Background:
- Urinary tract infections (UTIs) are common in children.
- Understanding the characteristics of urological flora is crucial for effective treatment.
- Pyelonephritis and cystitis are key forms of pediatric UTIs.
Purpose of the Study:
- To investigate the persistence properties of urological flora in children with UTIs.
- To establish the relationship between bacterial antilysozyme activity and the clinical presentation of pyelonephritis.
- To determine the prognostic significance of bacterial characteristics in pediatric UTIs.
Main Methods:
- Examination of 317 children diagnosed with pyelonephritis and cystitis.
- Determination of the persistence properties of isolated urological flora.
- Assessment of clinico-bacteriological correlations, focusing on antilysozyme activity.
Main Results:
- Enterobacteria, predominantly Escherichia, were the most prevalent urological flora in children with UTIs.
- A significant association was found between bacterial antilysozyme activity and the form and course of pyelonephritis.
- Urological strains with antilysozyme activity were more frequent in chronic (88.6%), relapsing, and latent pyelonephritis compared to cyclic courses.
Conclusions:
- Bacterial antilysozyme activity is a key factor in the pathogenesis and course of pediatric pyelonephritis.
- The prolonged isolation of urological flora with high antilysozyme activity has prognostic value for latent pyelonephritis.
- Identifying specific bacterial properties like antilysozyme activity can aid in predicting UTI outcomes in children.
Abstract:
317 children with pyelonephritis and cystitis were examined. The persistence properties of urological flora were determined. In most patients with infections of the urinary system, irrespective of the localization of the inflammatory process, enterobacteria (and more often Escherichia) prevailed. The clinico-bacteriological relationship between the antilysozyme activity of isolated bacteria and the form and course of the disease was established. In patients with chronic pyelonephritis urological strains with antilysozyme activity prevailed (88.6%); among children with the relapsing and latent course of pyelonephritis urological strains with such activity were isolated 4 times as frequently as from patients with the cyclic course of the disease. The prognostic value of the latent course of pyelonephritis was the prolonged isolation of urological flora with high antilysozyme activity.